From an early age, organisms display variation in patterns of behavioral and physiological reactivity, temperament, emotionality, and personality, a set of overlapping constructs referred to as biobehavioral organization. These patterns appear early in life and are remarkably stable over time. A growing literature, has focused on the origins of this variation as well as its consequences for a variety of health outcomes. Such an individualized approach is evident in development of the field of personalized medicine, and this approach is becoming increasingly adopted in more applied settings as well, including in the management of captive nonhuman primates. At the California National Primate Research Center we have developed a BioBehavioral Assessment (BBA) Program to characterize biobehavioral organization in infant rhesus monkeys. The BBA Program involves a highly standardized, 25-hour-long, protocol that includes a) collecting behavioral data to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of the serotonin transporter and monoamine oxidase-A genes; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. In addition to providing a database for scientific studies, the BBA Program contributes to the knowledge and improvement of the nonhuman primate resource at our own center, and published studies provide important information to management staff at other primate facilities in the United States as well. The following four specific aims are proposed: 1. Continue performing the BioBehavioral Assessment, and make these data available to management staff at CNPRC and qualified scientific staff at CNPRC and other institutions; 2. Incorporate into the BBA program a biomarker of inflammation, namely C-reactive protein, and examine the relationship between this marker and other BBA measures, as well as health outcomes; 3. Continue to examine causes and consequences of variation in BBA measures to better understand how biobehavioral organization is affected by management procedures, and to determine whether biobehavioral organization predicts abnormal behavior outcomes; 4. Improve dissemination of important colony management-related findings via both inreach efforts (focusing on education and training of individuals at CNPRC), and outreach efforts (for the larger nonhuman primate behavior management community).

Public Health Relevance

Recognition that not all individuals respond in the same way to challenge -- either microbial, physical, or social -- has led to recognition of the importance o individual characteristics in health and disease. This project will generate new knowledge regarding individual variation in biobehavioral organization, and how such variation relates to the health (behavioral and physical) of animals in our colony. By better understanding the causes and consequences of variation in biobehavioral organization, this program will result in improved nonhuman primate models for health-related research, and will provide a database that will be uniquely able to contribute to the development of primate models of personalized medicine.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Resource-Related Research Projects (R24)
Project #
5R24OD010962-13
Application #
9251921
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Zou, Sige
Project Start
2014-01-01
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
13
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of California Davis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Vandeleest, J J; Capitanio, J P; Hamel, A et al. (2018) Social stability influences the association between adrenal responsiveness and hair cortisol concentrations in rhesus macaques. Psychoneuroendocrinology 100:164-171
Walker, Cheryl K; VandeVoort, Catherine A; Li, Chin-Shang et al. (2018) Adiposity and weight gain during pregnancy associate independently with behavior of infant rhesus monkeys (Macaca mulatta). Dev Psychobiol 60:629-638
Bliss-Moreau, Eliza; Moadab, Gilda; Capitanio, John P (2017) Maternal rearing environment impacts autonomic nervous system activity. Dev Psychobiol 59:551-556
Capitanio, John P (2017) Naturally Occurring Nonhuman Primate Models of Psychosocial Processes. ILAR J 58:226-234
Golub, Mari S; Hackett, Edward P; Hogrefe, Casey E et al. (2017) Cognitive performance of juvenile monkeys after chronic fluoxetine treatment. Dev Cogn Neurosci 26:52-61
Madrid, Jesus E; Oztan, Ozge; Sclafani, Valentina et al. (2017) Preference for novel faces in male infant monkeys predicts cerebrospinal fluid oxytocin concentrations later in life. Sci Rep 7:12935
Capitanio, John P; Blozis, Shelley A; Snarr, Jessica et al. (2017) Do ""birds of a feather flock together"" or do ""opposites attract""? Behavioral responses and temperament predict success in pairings of rhesus monkeys in a laboratory setting. Am J Primatol 79:1-11
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Chun, Katie; Capitanio, John P (2016) Developmental consequences of behavioral inhibition: a model in rhesus monkeys (Macaca mulatta). Dev Sci 19:1035-1048
Golub, Mari S; Hogrefe, Casey E (2016) Sleep disturbance as detected by actigraphy in pre-pubertal juvenile monkeys receiving therapeutic doses of fluoxetine. Neurotoxicol Teratol 55:1-7

Showing the most recent 10 out of 45 publications