Abstract

The proposed research will continue experiments on the pathogenesis and treatment of encephalitozoonosis. The project will emphasize studies designed to alter the course of, or prevent infection with Encephalitozoon cuniculi. There will be studies designed to determine the impact of latent encephalitozoonosis on the research value of laboratory rodents and will try to show the pathogenetic mechanisms used by the parasite to alter host immune responses. Mechanisms used by the host to control parasite spread or multiplication will be investigated and evidence will be sought that some chronic renal disease is due to encephalitozoonosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Resource-Related Research Projects (R24)
Project #
5R24RR001294-07
Application #
3450513
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1981-04-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Veterinary Medicine
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820

  Publications

Liu, J J; Greeley, E H; Shadduck, J A (1989) Mechanisms of resistance/susceptibility to murine encephalitozoonosis. Parasite Immunol 11:241-56
Shadduck, J A; Baskin, G (1989) Serologic evidence of Encephalitozoon cuniculi infection in a colony of squirrel monkeys (Saimiri sciureus). Lab Anim Sci 39:328-30
Shadduck, J A (1989) Human microsporidiosis and AIDS. Rev Infect Dis 11:203-7
Liu, J J; Greeley, E H; Shadduck, J A (1988) Murine encephalitozoonosis: the effect of age and mode of transmission on occurrence of infection. Lab Anim Sci 38:675-9
Didier, E S; Shadduck, J A (1988) Modulated immune responsiveness associated with experimental Encephalitozoon cuniculi infection in BALB/c mice. Lab Anim Sci 38:680-4
Peterson, N; Liu, J A; Shadduck, J (1988) Encephalitozoon cuniculi: quantitation of parasites and evaluation of viability. J Protozool 35:430-4
Szabo, J R; Shadduck, J A (1988) Immunologic and clinicopathologic evaluation of adult dogs inoculated with Encephalitozoon cuniculi. J Clin Microbiol 26:557-63
Beckwith, C; Peterson, N; Liu, J J et al. (1988) Dot enzyme-linked immunosorbent assay (dot ELISA) for antibodies to Encephalitozoon cuniculi. Lab Anim Sci 38:573-6
Liu, J J; Shadduck, J A (1988) Encephalitozoon cuniculi infection in MRL/MPJ-LPR (lymphoproliferation) mice. Lab Anim Sci 38:685-8
Szabo, J R; Shadduck, J A (1987) Experimental encephalitozoonosis in neonatal dogs. Vet Pathol 24:99-108

Showing the most recent 10 out of 11 publications