The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. While the field of cancer epidemiology is moving rapidly toward a new era where interdisciplinary and multidisciplinary collaborative research is the central theme, there is a severe shortage of scientists working at the interfaces of the epidemiology, molecular biology, and genetics. We propose to establish the Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt-MAGEC) to equip postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey-research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer.
The specific aims of the Vanderbilt MAGEC are: (1) To recruit exceptional, ethnically diverse candidates (2 MD and 5 PhD) with strong backgrounds in epidemiology, genetics, and/or biology. Candidates will be recruited locally and nationally from among persons who have recently completed PhD degrees in relevant sciences (particularly epidemiology, genetics, biology, chemistry, biostatistics) or MDs with serious interests in cancer epidemiology research. (2) To develop and deliver individualized didactic training tailored to complement each trainee's prior training background and launch them along their desired career paths (molecular or genetic epidemiology of cancer). Specific training will consist of courses, seminars, studios, and a journal club. (3) To establish a multidisciplinary mentor team for each trainee and integrate all trainees into NCI-funded cancer epidemiology research projects. (4) To evaluate the impact of the Vanderbilt-MAGEC by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing papers in high-impact, peer-reviewed journals and submitting an NIH-quality grant proposal to an internal or external funding agency. Long-term outcomes will include cancer research career placements and NIH grant funding. This program, built upon an outstanding research and education training environment, an excellent body of researchers and educators, multiple, ongoing, cutting-edge research projects, exceptional data/biospecimen and population resources, and the rich history of interdisciplinary training at Vanderbilt, has an outstanding infrastructure and faculty to create an exemplary training program in the molecular and genetic epidemiology of cancer.

Public Health Relevance

The Vanderbilt training program in Molecular and Genetic Epidemiology of Cancer is designed to address the urgent need to build an elite class of epidemiologists to lead the new era of multidisciplinary collaborative research in cancer. The program, built upon an outstanding research and education training environment;excellent body of researchers and educators;multiple, ongoing, cutting-edge research projects;exceptional data/biospecimen and population resources;and the rich history of interdisciplinary training at Vanderbilt, will design and deliver individualized didactic and research training to equip postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey-research knowledge, and hands-on research and grant writing experience necessary to launch independent careers in the molecular and genetic epidemiology of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA160056-02
Application #
8545121
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2012-09-13
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$528,310
Indirect Cost
$36,171
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Varga, Matthew G; Cai, Hui; Waterboer, Tim et al. (2018) Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. Dig Dis Sci 63:2765-2772
Wu, Lang; Shi, Wei; Long, Jirong et al. (2018) A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nat Genet 50:968-978
Wu, Lang; Zheng, Wei; Xiang, Yong-Bing et al. (2018) Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev 27:479-487
Davenport, James R; Su, Timothy; Zhao, Zhiguo et al. (2018) Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps. Gut 67:456-465
Luu, Hung N; Cai, Hui; Murff, Harvey J et al. (2018) A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk. Int J Cancer 143:2225-2237
Hellwege, Jacklyn N; Russell, Shirley B; Williams, Scott M et al. (2018) Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann Hum Genet 82:206-215
Warren Andersen, Shaneda; Blot, William J; Shu, Xiao-Ou et al. (2018) Associations Between Neighborhood Environment, Health Behaviors, and Mortality. Am J Prev Med 54:87-95
Weigl, Korbinian; Thomsen, Hauke; Balavarca, Yesilda et al. (2018) Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population. Gastroenterology 155:88-98.e10
Varga, Matthew G; Wang, Tianyi; Cai, Hui et al. (2018) Helicobacter pylori Blood Biomarkers and Gastric Cancer Survival in China. Cancer Epidemiol Biomarkers Prev 27:342-344
Wang, Nan; Khankari, Nikhil K; Cai, Hui et al. (2017) Prediagnosis body mass index and waist-hip circumference ratio in association with colorectal cancer survival. Int J Cancer 140:292-301

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