Abstract

Mayo Clinic Nephrology & Urology Summer Undergraduate Research Fellowship (nuSURF) The Mayo Clinic has a rich history in both basic science and clinic science research in Nephrology & Urology, and has active PhD, MD and MD-PhD training programs. Annually, the Mayo Graduate School receives >1200 applications from Undergraduates to work with Mayo Clinic Investigators. The Mayo Clinic is home to both an O?Brien Urology Research Center as well as a Mayo Translational Polycystic Kidney Disease (PKD) Center. Both Mayo Centers are one of four NIH funded Centers in the US. For the past several years, both Centers have received supplemental funds to support summer undergraduate research related to kidney stones and PKD, respectively. This proposal (renewal), in response to RFA-DK-18-006 (R25) merges these three successful summer undergraduate programs (~115 students) into a more generalized Mayo Clinic Nephrology & Urology Summer Undergraduate Research Fellowship (nuSURF). Several students from Mayo?s programs have entered PhD, MD, or MD-PhD programs, or have co-authored Nephrology or Urology-oriented peer-reviewed papers. Over the next 5 years, we proposed to fund 14 students/summer (70 students total) through nuSURF to work specifically with Mayo Investigators engaged in basic or translational research in Nephrology & Urology. This 5 year period will allow undergraduates in the program to perform innovative Nephrology & Urology research with leading Mayo Clinic research laboratories. Students will also participate in various educational programs (e.g., weekly seminars and mini-courses) to enhance their research experience. Their 10-week summer experience will culminate with (1) a 10-minute oral presentation of their work, (2) a Mayo-wide Summer Undergraduate poster presentation (> 120 student/yr) and (3) a NIDDK-KUH Summer Undergraduate Research Symposium held annually at the end of the Summer at one of the funded R25-centers. Following the Summer Program, students will be academically tracked to determine the effectiveness of the Mayo nuSURF experience in Nephrology & Urology, basic research and clinical medicine. Our goal is to increase the number of basic and clinical Nephrology & Urology researchers as a result of this nuSURF training experience.

Public Health Relevance

Lay Summary The current proposal seeks to fund 14 undergraduate students annually to work with Mayo Clinic researchers in Nephrology or Urology. This 10-week summer program will pair undergraduates with Mayo Clinic researchers to carry out specific research projects. Additionally, students will participate in a research training course, take a cell and renal mini-course, organize their lab data into abstracts, oral research presentations and poster presentations. Talks will be given to Mayo faculty and posters will be presented at the NIDDK-KUH Summer Research Symposium held annually at the end of the Summer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Education Projects (R25)
Project #
5R25DK101405-07
Application #
9899976
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Rankin, Tracy L
Project Start
2014-04-01
Project End
2024-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

He, Kai; Ma, Xiaoyu; Xu, Tao et al. (2018) Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun 9:3310
Hommos, Musab S; De Vriese, An S; Alexander, Mariam P et al. (2017) The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study. Mayo Clin Proc 92:1772-1781
Ferrero, A; Gutjahr, R; Henning, A et al. (2017) Renal Stone Characterization using High Resolution Imaging Mode on a Photon Counting Detector CT System. Proc SPIE Int Soc Opt Eng 10132:
Eirin, Alfonso; Zhu, Xiang-Yang; Puranik, Amrutesh S et al. (2017) Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int 92:114-124
Kashyap, Sonu; Warner, Gina; Hu, Zeng et al. (2017) Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. PLoS One 12:e0187062
Tang, Xiaojing; Brown, Matthew R; Cogal, Andrea G et al. (2016) Functional and transport analyses of CLCN5 genetic changes identified in Dent disease patients. Physiol Rep 4:
Leng, Shuai; Huang, Alice; Cardona, Juan Montoya et al. (2016) Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study. AJR Am J Roentgenol 207:321-9
Turco, Anne E; Lam, Wing; Rule, Andrew D et al. (2016) Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. J Extracell Vesicles 5:29642
Ferrero, Andrea; Montoya, Juan C; Vaughan, Lisa E et al. (2016) Quantitative Prediction of Stone Fragility From Routine Dual Energy CT: Ex vivo proof of Feasibility. Acad Radiol 23:1545-1552
Landry, Greg M; Hirata, Taku; Anderson, Jacob B et al. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 310:F152-9

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