This renewal application stems from our successful first four years of a Bridge-to-the-Doctorate grant (South Texas Doctoral Bridge Program (STDBP; 2013-2017) supporting a partnership between the University of Texas Health Science Center at San Antonio (UT Health San Antonio; PhD-granting) and Texas State University ? San Marcos (TxState, master's granting). The overarching goal of the STDBP is to increase the number of individuals from populations underrepresented (UR) in the biomedical sciences with quality education, research training, and mentorship that will position them to enter the best doctoral programs in the nation. Our program objectives are to recruit and train UR TxState students to complete a thesis-based M.S. degree and to prepare them not only to be competitive for acceptance into top-ranked biomedical doctoral programs, but also to be successful once they matriculate into those programs. During the prior 4 year project term, 22 M.S. graduate students received financial support from the STDBP grant award and have been trained in basic research by a cadre of highly motivated and talented participating faculty. Over 70% (10/14) of the Bridge Scholars who have exited the program bridged successfully to doctoral programs within two years of enrolling in the M.S. program. These include 8 Bridge Scholars who graduated with M.S. degrees and are currently enrolled in doctoral programs (7 Ph.D. and 1 D.V.M.) at outstanding research-intensive institutions including; UT Health San Antonio, Baylor College of Medicine, Duke University, Johns Hopkins University, University of North Carolina (UNC) at Chapel Hill, and Dartmouth College, amongst others as well as 2 Bridge Scholars who did not complete the master's degree because they elected to, and have transition directly to Ph.D. programs (UNC Chapel Hill and University of Iowa respectively) after their first year in the Bridge program. All STDBP alumni that have bridged continue to do well in their doctoral programs and several have since garnered merit-based awards since matriculating. One of the two Bridge Scholars who graduated with M.S. degrees but are yet to bridge, has stated plans to apply this fall to professional programs and the other is assessing career options. Eight Bridge Scholars remain in M.S. training (5 of who will also apply to Ph.D. programs this year for Fall 2018 entry) and two were terminated from the program early on for not meeting programmatic requirements with one of the latter still at TxState completing the requirements for the M.S. degree. Therefore excluding those dismissed from the program, overall, 10/12 Bridge Scholars (83%) seamlessly transitioned to doctoral studies without any time lapse. In this first cycle, the STDBP developed a new course focused on critical thinking, experimental design & analysis and responsible conduct of research to strengthen the curriculum at TxState. This course is now established and incorporated into the core curriculum for all M.S. (Bridge and non-Bridge) students in the Chemistry & Biochemistry department. Building on these accomplishments, our vision in this STDBP renewal is to further increase the number of UR students who graduate from TxState and successfully bridge to top-tier doctoral programs nationwide. To accomplish this, we will use a combination of: (i) enhancement of the TxState curriculum by development of new contemporary curriculum in ?Genomics & Bioinformatics? and ?Scientific Rigor & Reproducibility?; (ii) innovative and targeted developmental activities designed to prepare Bridge Scholars to continue to be competitive for admission to, and success at, top-tier doctoral programs; and (iii) refinements in student recruitment strategies and student tracking as well as mentor training. This competing renewal application seeks continued support again for 6 trainees each year for 5 years.

Public Health Relevance

There is a need for a diverse biomedical research workforce able to address disparities in health and health care linked to race/ethnicity and socio-economic status amongst other factors. The overall goal of the South Texas Doctoral Bridge Program, a formal partnership between University of Texas Health Science Center at San Antonio (PhD granting institution) and Texas State University- San Marcos (master's degree-granting institution) is to increase the number of students from underrepresented minority (URM) populations who complete doctoral studies in the biomedical sciences. Through a series of programmatic activities involving rigorous didactic preparation, mentoring and experiential learning, URM students in the master's degree program at Texas State will be bridged into competitive and high quality PhD degree programs. This will prepare them for future careers in biomedical research and equip them with the skills and competencies to address health disparity issues.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Education Projects (R25)
Project #
5R25GM102783-07
Application #
9749170
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Brown, Patrick
Project Start
2013-09-13
Project End
2023-05-31
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Texas Health Science Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Gonzalez, Trevor J; Lu, Yuan; Boswell, Mikki et al. (2018) Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin. Comp Biochem Physiol C Toxicol Pharmacol 208:87-95
Gujjari, Archana; Rodriguez, Blanca V; Pescador, Jorge et al. (2018) Factors affecting the association of single- and double-stranded RNAs with montmorillonite nanoclays. Int J Biol Macromol 109:551-559
Lu, Yuan; Reyes, Jose; Walter, Sean et al. (2018) Characterization of basal gene expression trends over a diurnal cycle in Xiphophorus maculatus skin, brain and liver. Comp Biochem Physiol C Toxicol Pharmacol 208:2-11
Boswell, William T; Boswell, Mikki; Walter, Dylan J et al. (2018) Exposure to 4100K fluorescent light elicits sex specific transcriptional responses in Xiphophorus maculatus skin. Comp Biochem Physiol C Toxicol Pharmacol 208:96-104
Castro, José M; Horn, Daniel A; Pu, Xinzhu et al. (2017) Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein Expr Purif 134:147-153
English, Lance R; Tilton, Erin C; Ricard, Benjamin J et al. (2017) Intrinsic ? helix propensities compact hydrodynamic radii in intrinsically disordered proteins. Proteins 85:296-311
Villarreal, Michael A; Biediger, Nicole M; Bonner, Natalie A et al. (2017) Determining Zebrafish Epitope Reactivity to Commercially Available Antibodies. Zebrafish 14:387-389
Rodriguez, Blanca V; Malczewskyj, Eric T; Cabiya, Joshua M et al. (2016) Identification of RNase-resistant RNAs in Saccharomyces cerevisiae extracts: Separation from chromosomal DNA by selective precipitation. Anal Biochem 492:69-75
Chang, Jordan; Lu, Yuan; Boswell, William T et al. (2015) Molecular genetic response to varied wavelengths of light in Xiphophorus maculatus skin. Comp Biochem Physiol C Toxicol Pharmacol 178:104-15
Walter, Ronald B; Walter, Dylan J; Boswell, William T et al. (2015) Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin. Comp Biochem Physiol C Toxicol Pharmacol 178:93-103

Showing the most recent 10 out of 12 publications