During the past 5 years and with initial funding from the National Heart Lung Blood Institute (NHLBI), the Julius L. Chambers Biomedical/Biotechnology Research Institute (JLC-BBRI) at North Carolina Central University (NCCU) has collaborated with Duke University Medical Center (DUMC), Wake Forest University School of Medicine (WFUSM), and North Carolina State University (NCSU) to develop an effective and sustainable cardiovascular disease research program. Dr. Richard Bukoski joined the JLC-BBRI as Director of the Cardiovascular Disease Research Program and Professor of Biology in 1999. Since that time, he worked in close collaboration to plan and develop an interinstitutional, collaborative, interdisciplinary cardiovascular disease research program that focuses on African American health disparities. The goals have been to: support research in cardiovascular science;provide laboratory training experiences for selected undergraduate and graduate students;forge collaborative research and education arrangements with the academic community;attract other biomedical science faculty to NCCU;strengthen the science curriculum;and arrange for science seminars and collaborative exchange activities. Therefore, the aims of this proposal are designed to sustain and continue to grow and develop the JLC-BBRI Cardiovascular Disease Research Program. With input from the Joint Planning Committee the Program has identified three Specific Aims that support its overall goals:
Specific Aim 1 is to support and promote ongoing projects/programs initiated by members of the NCCU Cardiovascular Disease Research Team.
Specific Aim 2 is designed to establish a formal career development program aimed at increasing the number of minority scientists conducting research on cardiovascular physiology and disease.
Specific Aim 3 will be to expand the JLC-BBRI's Education and Training Program to provide academic year and summer research experiences for NCCU students.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Education Projects (R25)
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Special Emphasis Panel (ZHL1-CSR-G (M2))
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Paltoo, Dina
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North Carolina Central University
Other Domestic Higher Education
United States
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Wilkins, Jeffrey; Ghosh, Palash; Vivar, Juan et al. (2018) Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005-2008. BMC Obes 5:21
Pointer, Mildred A; Eley, Shaleka; Anderson, Lauren et al. (2015) Differential Effect of Renal Cortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-Sensitive Hypertension. Am J Hypertens 28:1049-55
Sesay, John S; Gyapong, Reginald N K; Najafi, Leila T et al. (2015) G?i/o-dependent Ca(2+) mobilization and G?q-dependent PKC? regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Neurochem Int 90:142-51
Spruiell, Krisstonia; Jones, Dominique Z; Cullen, John M et al. (2014) Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. Biochem Pharmacol 89:399-412
Ghosh, Sujoy; Vivar, Juan C; Sarzynski, Mark A et al. (2013) Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training. J Appl Physiol (1985) 115:1343-59
Awumey, Emmanuel M; Bridges, Lakeesha E; Williams, Cicely L et al. (2013) Nitric-oxide synthase knockout modulates Ca²?-sensing receptor expression and signaling in mouse mesenteric arteries. J Pharmacol Exp Ther 346:38-47
van Greevenbroek, M M J; Ghosh, S; van der Kallen, C J H et al. (2012) Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance. J Clin Endocrinol Metab 97:4742-52
Pointer, Mildred A; Daumerie, Geraldine; Bridges, LaKessha et al. (2012) Physiological stress increases renal injury in eNOS-knockout mice. Hypertens Res 35:318-24
Pemu, Priscilla E; Anderson, Leonard; Gee, Beatrice E et al. (2012) Early alterations of the immune transcriptome in cultured progenitor cells from obese African-American women. Obesity (Silver Spring) 20:1481-90
Ghosh, Sujoy; Dent, Robert; Harper, Mary E et al. (2011) Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction. Obesity (Silver Spring) 19:457-63

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