Neuroimaging has become the central method for the analysis of human brain function. It holds promise of clarifying systems-level pathophysiology of mental disorders, and transforming their diagnosis and treatment. """"""""Seeing"""""""" the brain in action is itself a powerful motivator for students and professionals. At the New York Hospital-Cornell Medical Center we have developed two laboratories concerned with imaging both adults (Functional Neuroimaging Laboratory) and children (Sackler Institute). We propose to develop a national training center for clinical investigators in Cognitive Neuropsychiatric imaging. By clinical, we mean to include disorders of the central nervous system of the type commonly considered psychiatric, including schizophrenia and depression, as well as those more commonly called developmental such as autism, attention deficit hyperactivity disorder and learning disabilities. By neuroimaging we mean to include hemodynamic methods such as PET and fMRI as well as electrical recording from inside or outside the brain. We plan both to train professional clinical researchers in psychiatry, psychology and related fields, and to develop and test materials here at Cornell Medical Center that may be used in medical school, psychiatry and psychology departments, and in pediatric programs in the U S. and abroad.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Education Projects (R25)
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Special Emphasis Panel (ZMH1-CRB-J (03))
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Wynne, Debra K
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Dincheva, Iva; Drysdale, Andrew T; Hartley, Catherine A et al. (2015) FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nat Commun 6:6395
Bath, Kevin G; Jing, Deqiang Q; Dincheva, Iva et al. (2012) BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology 37:1297-304
Bath, Kevin G; Chuang, Jocelyn; Spencer-Segal, Joanna L et al. (2012) Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biol Psychiatry 72:499-504
Bath, Kevin G; Akins, Michael R; Lee, Francis S (2012) BDNF control of adult SVZ neurogenesis. Dev Psychobiol 54:578-89
Yang, Jianfeng; Wang, Xiaojuan; Shu, Hua et al. (2011) Brain networks associated with sublexical properties of Chinese characters. Brain Lang 119:68-79
Magarinos, A M; Li, C J; Gal Toth, J et al. (2011) Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons. Hippocampus 21:253-64
Pattwell, Siobhan S; Bath, Kevin G; Casey, B J et al. (2011) Selective early-acquired fear memories undergo temporary suppression during adolescence. Proc Natl Acad Sci U S A 108:1182-7
Soliman, Fatima; Glatt, Charles E; Bath, Kevin G et al. (2010) A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327:863-6
Casey, B J; Soliman, Fatima; Bath, Kevin G et al. (2010) Imaging genetics and development: challenges and promises. Hum Brain Mapp 31:838-51
Ninan, Ipe; Bath, Kevin G; Dagar, Karishma et al. (2010) The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. J Neurosci 30:8866-70

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