The relationship between alcohol use among adult women during pregnancy and fetal outcome has been a major area of interest for the past two decades. A widespread prevalence of alcohol use among teenagers has also been shown, which is of particular concern given the high risk of fetal, perinatal and maternal morbidity and mortality with teenage mothers. However, despite these observations, the relationship between alcohol use during pregnancy and fetal outcome has never been evaluated using an adolescent population. This proposed study will: 1) Examine the relationship between prenatal alcohol use among adolescents and infant outcome with respect to the infant's physical and developmental abnormalities. 2) Assess the prevalence of alcohol and other drug use among pregnant adolescents prior to pregnancy and during each trimester. 3) Examine how demographic, psycho-social variables and knowledge and attitudes about drinking during pregnancy relate to actual drinking. The effect of alcohol use will be assessed one month prior to pregnancy and during each trimester. Careful analysis of socio-demographic characteristics, other drug use, nutritional status and gynecological age will permit separation of the direct teratogenic effect of alcohol use from the contribution of other factors that may accompany alcohol use in the pregnant teenager. Infant examinations will include birthweight, birth length, head and chest circumference, APGAR scores, ponderal index, Brazelton Neonatal Behavioral Assessment Scale and the Osofsky Danzger Feeding Observation. Subjects for this study will be obtained from the prenatal clinic at the Magee-Womens Hospital in Pittsburgh, PA. Data will be collected over a four year period and it is estimated that information on 600 adolescents (under age eighteen) and their infants will be obtained.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AA008284-02
Application #
3452856
Study Section
Clinical and Treatment Subcommittee (ALCP)
Project Start
1989-09-29
Project End
1994-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
De Genna, Natacha M; Goldschmidt, Lidush; Day, Nancy L et al. (2016) Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use. Nicotine Tob Res 18:988-92
De Genna, Natacha M; Cornelius, Marie D (2015) Maternal drinking and risky sexual behavior in offspring. Health Educ Behav 42:185-93
De Genna, Natacha M; Goldschmidt, Lidush; Cornelius, Marie D (2015) Maternal patterns of marijuana use and early sexual behavior in offspring of teenage mothers. Matern Child Health J 19:626-34
Hardaway, Cecily R; Cornelius, Marie D (2014) Economic hardship and adolescent problem drinking: family processes as mediating influences. J Youth Adolesc 43:1191-202
Cornelius, Marie D; Goldschmidt, Lidush; De Genna, Natacha M et al. (2012) Long-term effects of prenatal cigarette smoke exposure on behavior dysregulation among 14-year-old offspring of teenage mothers. Matern Child Health J 16:694-705
Cornelius, Marie D; De Genna, Natacha M; Leech, Sharon L et al. (2011) Effects of prenatal cigarette smoke exposure on neurobehavioral outcomes in 10-year-old children of adolescent mothers. Neurotoxicol Teratol 33:137-44
Cornelius, Marie D; Goldschmidt, Lidush; De Genna, Natacha M et al. (2010) Improvement in intelligence test scores from 6 to 10 years in children of teenage mothers. J Dev Behav Pediatr 31:405-13
Cornelius, Marie D; Goldschmidt, Lidush; Willford, Jennifer A et al. (2009) Body size and intelligence in 6-year-olds: are offspring of teenage mothers at risk? Matern Child Health J 13:847-56
De Genna, Natacha M; Cornelius, Marie D; Donovan, John E (2009) Risk factors for young adult substance use among women who were teenage mothers. Addict Behav 34:463-70
Cornelius, Marie D; Day, Nancy L (2009) Developmental consequences of prenatal tobacco exposure. Curr Opin Neurol 22:121-5

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