Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AA010399-01A2
Application #
2047029
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Gibbons, Brian J; Hurley, Thomas D (2004) Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry 43:12555-62
Sanghani, Paresh C; Robinson, Howard; Bennett-Lovsey, Riccardo et al. (2003) Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase). Chem Biol Interact 143-144:195-200
Sanghani, Paresh C; Bosron, William F; Hurley, Thomas D (2002) Human glutathione-dependent formaldehyde dehydrogenase. Structural changes associated with ternary complex formation. Biochemistry 41:15189-94
Sanghani, Paresh C; Robinson, Howard; Bosron, William F et al. (2002) Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes. Biochemistry 41:10778-86
Niederhut, M S; Gibbons, B J; Perez-Miller, S et al. (2001) Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci 10:697-706
Xie, P T; Hurley, T D (1999) Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase. Protein Sci 8:2639-44
Hurley, T D; Steinmetz, C G; Weiner, H (1999) Three-dimensional structure of mitochondrial aldehyde dehydrogenase. Mechanistic implications. Adv Exp Med Biol 463:15-25
Yang, Z N; Bosron, W F; Hurley, T D (1997) Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. J Mol Biol 265:330-43
Xie, P; Parsons, S H; Speckhard, D C et al. (1997) X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity. J Biol Chem 272:18558-63
Hurley, T D; Steinmetz, C G; Xie, P et al. (1997) Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity. Adv Exp Med Biol 414:291-302