Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AG010869-05
Application #
2052087
Study Section
Neurology A Study Section (NEUA)
Project Start
1992-08-01
Project End
1998-06-30
Budget Start
1996-07-10
Budget End
1998-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Charlotte
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Charlotte
State
NC
Country
United States
Zip Code
28223
Rockenstein, Edward; Mante, Michael; Alford, Michael et al. (2005) High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem 280:32957-67
Song, David D; Shults, Clifford W; Sisk, Abbyann et al. (2004) Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp Neurol 186:158-72
Rockenstein, E; Adame, A; Mante, M et al. (2003) The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance. J Neural Transm 110:1313-27
Hashimoto, Makoto; Masliah, Eliezer (2003) Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies. Neurochem Res 28:1743-56
Kennedy, B P; Ziegler, M G; Alford, M et al. (2003) Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease. J Neural Transm 110:789-801
Veinbergs, Isaac; Everson, Analisa; Sagara, Yutaka et al. (2002) Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J Neurosci Res 67:379-87
Wyss-Coray, Tony; Yan, Fengrong; Lin, Amy Hsiu-Ti et al. (2002) Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A 99:10837-42
Rockenstein, E; Mallory, M; Mante, M et al. (2002) Effects of Cerebrolysin on amyloid-beta deposition in a transgenic model of Alzheimer's disease. J Neural Transm Suppl :327-36
Rockenstein, Edward; Mallory, Margaret; Hashimoto, Makoto et al. (2002) Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 68:568-78
Veinbergs, I; Van Uden, E; Mallory, M et al. (2001) Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E. Exp Neurol 170:15-26

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