Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29AI025563-05
Application #
3454480
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1988-07-01
Project End
1993-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Tobias, P S; Gegner, J; Han, J et al. (1994) LPS binding protein and CD14 in the LPS dependent activation of cells. Prog Clin Biol Res 388:31-9
Goldblum, S E; Brann, T W; Ding, X et al. (1994) Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro. J Clin Invest 93:692-702
Pugin, J; Schurer-Maly, C C; Leturcq, D et al. (1993) Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A 90:2744-8
Weingarten, R; Sklar, L A; Mathison, J C et al. (1993) Interactions of lipopolysaccharide with neutrophils in blood via CD14. J Leukoc Biol 53:518-24
Mathison, J; Wolfson, E; Steinemann, S et al. (1993) Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages. J Clin Invest 92:2053-9
Roth, R I; Tobias, P S (1993) Lipopolysaccharide-binding proteins of Limulus amebocyte lysate. Infect Immun 61:1033-9
Tobias, P S; Soldau, K; Kline, L et al. (1993) Cross-linking of lipopolysaccharide (LPS) to CD14 on THP-1 cells mediated by LPS-binding protein. J Immunol 150:3011-21
Lee, J D; Kato, K; Tobias, P S et al. (1992) Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J Exp Med 175:1697-705
Tobias, P S; Mathison, J; Mintz, D et al. (1992) Participation of lipopolysaccharide-binding protein in lipopolysaccharide-dependent macrophage activation. Am J Respir Cell Mol Biol 7:239-45
Mathison, J C; Tobias, P S; Wolfson, E et al. (1992) Plasma lipopolysaccharide (LPS)-binding protein. A key component in macrophage recognition of gram-negative LPS. J Immunol 149:200-6

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