Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29AI030104-05
Application #
3455626
Study Section
Experimental Immunology Study Section (EI)
Project Start
1990-07-01
Project End
1995-04-30
Budget Start
1994-01-01
Budget End
1994-04-30
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wagoner, L E; Zhao, L; Bishop, D K et al. (1996) Lysis of adult ventricular myocytes by cells infiltrating rejecting murine cardiac allografts. Circulation 93:111-9
DeBruyne, L A; Chang, A E; Cameron, M J et al. (1996) Direct transfer of a foreign MHC gene into human melanoma alters T cell receptor V beta usage by tumor-infiltrating lymphocytes. Cancer Immunol Immunother 43:49-58
DeBruyne, L A; Renlund, D G; Bishop, D K (1995) Evidence that human cardiac allograft acceptance is associated with a decrease in donor-reactive helper T lymphocytes. Transplantation 59:778-83
Bishop, D K; DeBruyne, L A; Chan, S et al. (1995) Dissociation of mouse cardiac transplant rejection and donor alloantigen-specific T cell responsiveness. Transpl Immunol 3:222-8
Chan, S Y; DeBruyne, L A; Goodman, R E et al. (1995) In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 59:1155-61
Bishop, D K; Li, W; Chan, S Y et al. (1994) Helper T lymphocyte unresponsiveness to cardiac allografts following transient depletion of CD4-positive cells. Implications for cellular and humoral responses. Transplantation 58:576-84
Bishop, D K; Chan, S; Li, W et al. (1993) CD4-positive helper T lymphocytes mediate mouse cardiac allograft rejection independent of donor alloantigen specific cytotoxic T lymphocytes. Transplantation 56:892-7
Bishop, D K; Shelby, J; Eichwald, E J (1992) Mobilization of T lymphocytes following cardiac transplantation. Evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection. Transplantation 53:849-57
Bishop, D K; Li, W (1992) Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo. J Immunol 148:1049-54
Bishop, D K; Shelby, J; Eichwald, E J (1991) Functional analysis of donor-reactive T cells infiltrating heterotopic cardiac transplants: effect of anti-CD4 MAb in vivo. Transplant Proc 23:287-9