Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29AI031615-05
Application #
2066610
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1991-08-01
Project End
1997-05-31
Budget Start
1995-06-01
Budget End
1997-05-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Washington University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Mamoun, C B; Goldberg, D E (2001) Plasmodium protein phosphatase 2C dephosphorylates translation elongation factor 1beta and inhibits its PKC-mediated nucleotide exchange activity in vitro. Mol Microbiol 39:973-81
Mamoun, C B; Truong, R; Gluzman, I et al. (1999) Transfer of genes into Plasmodium falciparum by polyamidoamine dendrimers. Mol Biochem Parasitol 103:117-21
Le Bonniec, S; Deregnaucourt, C; Redeker, V et al. (1999) Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. J Biol Chem 274:14218-23
Mamoun, C B; Gluzman, I Y; Goyard, S et al. (1999) A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A 96:8716-20
Eggleson, K K; Duffin, K L; Goldberg, D E (1999) Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum. J Biol Chem 274:32411-7
Mamoun, C B; Sullivan Jr, D J; Banerjee, R et al. (1998) Identification and characterization of an unusual double serine/threonine protein phosphatase 2C in the malaria parasite Plasmodium falciparum. J Biol Chem 273:11241-7
Shear, H L; Grinberg, L; Gilman, J et al. (1998) Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism. Blood 92:2520-6
Francis, S E; Sullivan Jr, D J; Goldberg, D E (1997) Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu Rev Microbiol 51:97-123
Goldberg, D E; Sharma, V; Oksman, A et al. (1997) Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes. J Biol Chem 272:6567-72
Francis, S E; Banerjee, R; Goldberg, D E (1997) Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II. J Biol Chem 272:14961-8

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