Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI032506-05
Application #
2067410
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1992-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Yeaman, M R; Bayer, A S; Koo, S P et al. (1998) Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. J Clin Invest 101:178-87
Sullam, P M; Hyun, W C; Szollosi, J et al. (1998) Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane. J Biol Chem 273:5331-6
Baker, G R; Sullam, P M; Levin, J (1997) A simple, fluorescent method to internally label platelets suitable for physiological measurements. Am J Hematol 56:17-25
Sullam, P M; Bayer, A S; Foss, W M et al. (1996) Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect Immun 64:4915-21
Bayer, A S; Sullam, P M; Ramos, M et al. (1995) Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb/IIIa fibrinogen-binding domains. Infect Immun 63:3634-41
Yeaman, M R; Sullam, P M; Dazin, P F et al. (1994) Platelet microbicidal protein alone and in combination with antibiotics reduces Staphylococcus aureus adherence to platelets in vitro. Infect Immun 62:3416-23
Cheung, A L; Yeaman, M R; Sullam, P M et al. (1994) Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits. Infect Immun 62:1719-25
Cheung, A L; Eberhardt, K J; Chung, E et al. (1994) Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest 94:1815-22
Sullam, P M; Costerton, J W; Yamasaki, R et al. (1993) Inhibition of platelet binding and aggregation by streptococcal exopolysaccharide. J Infect Dis 167:1123-30
Sullam, P M; Frank, U; Yeaman, M R et al. (1993) Effect of thrombocytopenia on the early course of streptococcal endocarditis. J Infect Dis 168:910-4