Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI032726-04
Application #
2067614
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1992-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hawdon, J M; Hotez, P J (1996) Hookworm: developmental biology of the infectious process. Curr Opin Genet Dev 6:618-23
Hawdon, J M; Jones, B F; Hoffman, D R et al. (1996) Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae. J Biol Chem 271:6672-8
Cappello, M; Hawdon, J M; Jones, B F et al. (1996) Ancylostoma caninum anticoagulant peptide: cloning by PCR and expression of soluble, active protein in E. coli. Mol Biochem Parasitol 80:113-7
Hotez, P J; Hawdon, J M; Cappello, M et al. (1996) Molecular approaches to vaccinating against hookworm disease. Pediatr Res 40:515-21
Hawdon, J M (1996) Differentiation between the human hookworms Ancylostoma duodenale and Necator americanus using PCR-RFLP. J Parasitol 82:642-7
Cappello, M; Vlasuk, G P; Bergum, P W et al. (1995) Ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor Xa. Proc Natl Acad Sci U S A 92:6152-6
Hawdon, J M; Jones, B F; Hotez, P J (1995) Cloning and characterization of a cDNA encoding the catalytic subunit of a cAMP-dependent protein kinase from Ancylostoma caninum third-stage infective larvae. Mol Biochem Parasitol 69:127-30
Hawdon, J M; Jones, B F; Perregaux, M A et al. (1995) Ancylostoma caninum: metalloprotease release coincides with activation of infective larvae in vitro. Exp Parasitol 80:205-11
Hotez, P J; Hawdon, J M; Cappello, M et al. (1995) Molecular pathobiology of hookworm infection. Infect Agents Dis 4:71-5