Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29AI033587-03
Application #
2068640
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-01-01
Budget End
1996-04-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
St. Vincent Medical Center
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90057
Shirwan, Haval; Mhoyan, Anna; Kakoulidis, Thanos P et al. (2003) Prevention of chronic rejection with immunoregulatory cells induced by intrathymic immune modulation with class I allopeptides. Am J Transplant 3:581-9
Singh, N P; Shirwan, H (2001) The role of indirect recognition and TH2 response in cardiac xenograft rejection. Transplant Proc 33:746
Yolcu, E; Fang, J; Shirwan, H (2001) Autoimmune responses regulate alloimmunity for prolonged cardiac allograft survival. Transplant Proc 33:93
Cherradi, S L; Shirwan, H (2001) Expression of FasL as a stable cell-surface molecule is important to its apoptotic function. Transplant Proc 33:259
Shirwan, H; Mhoyan, A; Yolcu, E et al. (2001) Intrathymic immune regulation with donor class I allopeptides leads to the development of immunoregulatory cells that maintain tolerance to cardiac allografts. Transplant Proc 33:80
Shirwan, H; Barwari, L; Khan, N S (1999) Immune nonresponsiveness to cardiac allografts by intrathymic inoculation of donor class I allopeptides is associated with high levels of transcripts for Th2 cytokines in the graft. Transplant Proc 31:123-4
Huang, Y; Neipp, M; Ildstad, S T et al. (1999) Rat peripheral T-cell receptor V beta repertoire in F344-to-B10 (rat-to-mouse) mixed xenogeneic chimeras. Transplant Proc 31:978-9
Shirwan, H (1999) Chronic allograft rejection. Do the Th2 cells preferentially induced by indirect alloantigen recognition play a dominant role? Transplantation 68:715-26
Shirwan, H; Barwari, L; Khan, N S (1998) Predominant expression of T helper 2 cytokines and altered expression of T helper 1 cytokines in long-term allograft survival induced by intrathymic immune modulation with donor class I major histocompatibility complex peptides. Transplantation 66:1802-9
Shirwan, H; Wu, G D; Barwari, L et al. (1997) Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. II. Evidence for persistent chronic rejection despite high levels of donor microchimerism. Transplantation 64:1671-6

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