Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI034073-02
Application #
2069162
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1995-09-15
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Stephen, Tom Li; Niemeyer, Marcus; Tzianabos, Arthur O et al. (2005) Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation. Infect Immun 73:2184-9
Kalka-Moll, Wiltrud M; Tzianabos, Arthur O; Bryant, Paula W et al. (2002) Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J Immunol 169:6149-53
Kalka-Moll, W M; Wang, Y; Comstock, L E et al. (2001) Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain. Infect Immun 69:2339-44
Tzianabos, A O; Wang, J Y; Lee, J C (2001) Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides. Proc Natl Acad Sci U S A 98:9365-70
Kalka-Moll, W M; Tzianabos, A O; Wang, Y et al. (2000) Effect of molecular size on the ability of zwitterionic polysaccharides to stimulate cellular immunity. J Immunol 164:719-24
Tzianabos, A O; Finberg, R W; Wang, Y et al. (2000) T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria. J Biol Chem 275:6733-40
Tzianabos, A O; Chandraker, A; Kalka-Moll, W et al. (2000) Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway. Infect Immun 68:6650-5
Comstock, L E; Coyne, M J; Tzianabos, A O et al. (1999) Analysis of a capsular polysaccharide biosynthesis locus of Bacteroides fragilis. Infect Immun 67:3525-32
Tzianabos, A O; Russell, P R; Onderdonk, A B et al. (1999) IL-2 mediates protection against abscess formation in an experimental model of sepsis. J Immunol 163:893-7
Tzianabos, A O; Gibson 3rd, F C; Cisneros, R L et al. (1998) Protection against experimental intraabdominal sepsis by two polysaccharide immunomodulators. J Infect Dis 178:200-6

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