HIV-1 Protease Inhibitor Resistance

Kaplan, Andrew H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29AI036702-03
• Application #: 2073153
• Study Section: AIDS and Related Research Study Section 3 (ARRC)
• Project Start: 1994-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of California Los Angeles
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 119132785
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90095

Publications

Pettit, Steven C; Gulnik, Sergei; Everitt, Lori et al. (2003) The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage. J Virol 77:366-74

Dorman, Karin S; Kaplan, Andrew H; Sinsheimer, Janet S (2002) Bootstrap confidence levels for HIV-1 recombination. J Mol Evol 54:200-9

Lech, W J; Wang, G; Yang, Y L et al. (1996) In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects. J Virol 70:2038-43

Kaplan, A H; Manchester, M; Smith, T et al. (1996) Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication. J Virol 70:5840-4