Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI038715-02
Application #
2075814
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Simon, J H; Carpenter, E A; Fouchier, R A et al. (1999) Vif and the p55(Gag) polyprotein of human immunodeficiency virus type 1 are present in colocalizing membrane-free cytoplasmic complexes. J Virol 73:2667-74
Simon, J H; Sheehy, A M; Carpenter, E A et al. (1999) Mutational analysis of the human immunodeficiency virus type 1 Vif protein. J Virol 73:2675-81
Simon, J H; Miller, D L; Fouchier, R A et al. (1998) The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: a role for Vif in determining virus host range and cross-species transmission. EMBO J 17:1259-67
Simon, J H; Miller, D L; Fouchier, R A et al. (1998) Virion incorporation of human immunodeficiency virus type-1 Vif is determined by intracellular expression level and may not be necessary for function. Virology 248:182-7
Simon, J H; Gaddis, N C; Fouchier, R A et al. (1998) Evidence for a newly discovered cellular anti-HIV-1 phenotype. Nat Med 4:1397-400
Simon, J H; Fouchier, R A; Southerling, T E et al. (1997) The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells. J Virol 71:5259-67
Fouchier, R A; Meyer, B E; Simon, J H et al. (1997) HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import. EMBO J 16:4531-9
Fouchier, R A; Simon, J H; Jaffe, A B et al. (1996) Human immunodeficiency virus type 1 Vif does not influence expression or virion incorporation of gag-, pol-, and env-encoded proteins. J Virol 70:8263-9
Simon, J H; Malim, M H (1996) The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes. J Virol 70:5297-305