The adaptive immune response to pathogens initiated by CD4+ T-cells can take two distinct forms, referred to as humoral and cell-mediated immunity. Factors such as hormones, cytokines, adjuvants and antigen presenting cells (APC) are thought to influence skewing of T-cell responses. Based on preliminary data, the investigator postulates that the form of the antigen (e.g. peptide or protein or microbial-derived) used to prime a CD4+ T-cell will also have a bearing on subsequent responses through the preferential usage of APC subsets. Using both in vivo and in vitro approaches, the investigator will address this issue in two specific aims. The investigator will determine if peptide and protein antigens can induce differential CD4+ T-cell priming through their interaction with different APC, and seeks to identify the APC requirements for microbial-derived and viral-derived antigens during CD4+ T-cell priming.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI039158-05
Application #
6169327
Study Section
Immunological Sciences Study Section (IMS)
Program Officer
Hackett, Charles J
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
5
Fiscal Year
2000
Total Cost
$131,635
Indirect Cost
Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Constant, S L; Bottomly, K (1997) Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15:297-322