Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI040263-05
Application #
6170053
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Quackenbush, Robert L
Project Start
1996-07-01
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2002-06-30
Support Year
5
Fiscal Year
2000
Total Cost
$97,143
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Thomas, K L; Leduc, I; Olsen, B et al. (2001) Cloning, overexpression, purification, and immunobiology of an 85-kilodalton outer membrane protein from Haemophilus ducreyi. Infect Immun 69:4438-46
Bauer, M E; Goheen, M P; Townsend, C A et al. (2001) Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers. Infect Immun 69:2549-57
Bong, C T; Throm, R E; Fortney, K R et al. (2001) DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers. Infect Immun 69:1488-91
Elkins, C; Yi, K; Olsen, B et al. (2000) Development of a serological test for Haemophilus ducreyi for seroprevalence studies. J Clin Microbiol 38:1520-6
Elkins, C; Morrow Jr, K J; Olsen, B (2000) Serum resistance in Haemophilus ducreyi requires outer membrane protein DsrA. Infect Immun 68:1608-19
Al-Tawfiq, J A; Fortney, K R; Katz, B P et al. (2000) An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection. J Infect Dis 181:1049-54
Thomas, C E; Olsen, B; Elkins, C (1998) Cloning and characterization of tdhA, a locus encoding a TonB-dependent heme receptor from Haemophilus ducreyi. Infect Immun 66:4254-62
Elkins, C; Totten, P A; Olsen, B et al. (1998) Role of the Haemophilus ducreyi Ton system in internalization of heme from hemoglobin. Infect Immun 66:151-60