Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AR041210-05
Application #
2080558
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1992-09-15
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Henry Ford Health System
Department
Orthopedics
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202
Liu, Zhongbo; Kennedy, Oran D; Cardoso, Luis et al. (2016) DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J 30:635-52
Cheung, Wing Yee; Fritton, J Christopher; Morgan, Stacy Ann et al. (2016) Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes. J Bone Miner Res 31:890-9
Cardoso, Luis; Schaffler, Mitchell B (2015) Changes of elastic constants and anisotropy patterns in trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound. J Biomech Eng 137:
Seref-Ferlengez, Zeynep; Basta-Pljakic, Jelena; Kennedy, Oran D et al. (2014) Structural and mechanical repair of diffuse damage in cortical bone in vivo. J Bone Miner Res 29:2537-44
Kennedy, Oran D; Sun, Hui; Wu, Yingjie et al. (2014) Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology 155:987-99
Kennedy, Oran D; Laudier, Damien M; Majeska, Robert J et al. (2014) Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone 64:132-7
Schaffler, Mitchell B; Cheung, Wing-Yee; Majeska, Robert et al. (2014) Osteocytes: master orchestrators of bone. Calcif Tissue Int 94:5-24
Mullen, C A; Haugh, M G; Schaffler, M B et al. (2013) Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation. J Mech Behav Biomed Mater 28:183-94
Wu, Yingjie; Sun, Hui; Basta-Pljakic, Jelena et al. (2013) Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor. J Bone Miner Res 28:1575-86
Kennedy, Oran D; Herman, Brad C; Laudier, Damien M et al. (2012) Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone 50:1115-22

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