Models of polyamine/DNA interactions will be developed using computer graphics and molecular mechanics, and characterized by various physical chemical techniques. The models will be used to select analogues of polyamines based upon their interaction with DNA. The analogues will be characterized theoretically, synthesized, and tested using both physical chemical techniques and cell culture. The hope is to better understand polyamine/DNA interactions, and to use this understanding in design of cancer chemotherapeutic agents.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA041757-03
Application #
3457884
Study Section
Biochemistry Study Section (BIO)
Project Start
1986-12-01
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143