Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29CA042111-01
Application #
3457887
Study Section
Radiation Study Section (RAD)
Project Start
1986-07-01
Project End
1989-04-30
Budget Start
1986-07-01
Budget End
1987-04-30
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Uckun, F M; Myers, D E; Irvin, J D et al. (1993) Effects of the intermolecular toxin-monoclonal antibody linkage on the in vivo stability, immunogenicity and anti-leukemic activity of B43 (anti-CD19) pokeweed antiviral protein immunotoxin. Leuk Lymphoma 9:459-76
Chae, H P; Jarvis, L J; Uckun, F M (1993) Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells. Cancer Res 53:447-51
Schieven, G L; Kirihara, J M; Gilliland, L K et al. (1993) Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes. Mol Biol Cell 4:523-30
Gunther, R; Chelstrom, L M; Finnegan, D et al. (1993) In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency. Leukemia 7:298-309
Uckun, F M; Jaszcz, W; Chandan-Langlie, M et al. (1993) Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia. J Clin Invest 91:1044-51
Uckun, F M; Song, C W (1993) Lack of CD24 antigen expression in B-lineage acute lymphoblastic leukemia is associated with intrinsic radiation resistance of primary clonogenic blasts. Blood 81:1323-32
Uckun, F M; Chandan-Langlie, M; Jaszcz, W et al. (1993) Radiation damage repair capacity of primary clonogenic blasts in acute lymphoblastic leukemia. Cancer Res 53:1431-6
Uckun, F M; Schieven, G L; Tuel-Ahlgren, L M et al. (1993) Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proc Natl Acad Sci U S A 90:252-6
Uckun, F M; Chelstrom, L M; Finnegan, D et al. (1992) Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide. Blood 79:3116-29
Uckun, F M; Song, C W; Nesbit, M et al. (1992) Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys 24:705-12

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