Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29CA044602-03
Application #
3458046
Study Section
Pathology B Study Section (PTHB)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1990-01-08
Budget End
1990-01-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Nishikawa, Y; Wang, M; Carr, B I (1998) Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. J Cell Physiol 176:612-23
Nishikawa, Y; Kar, S; Wiest, L et al. (1997) Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. Biochem J 321 ( Pt 2):537-43
Hasegawa, K; Wang, Z; Inagaki, M et al. (1995) Characterization of a human hepatoma cell line with acquired resistance to growth inhibition by transforming growth factor beta 1 (TGF-beta 1). In Vitro Cell Dev Biol Anim 31:55-61
Polimeno, L; Azzarone, A; Zeng, Q H et al. (1995) Cell proliferation and oncogene expression after bile duct ligation in the rat: evidence of a specific growth effect on bile duct cells. Hepatology 21:1070-8
Inagaki, M; Wang, Z; Carr, B I (1994) Transforming growth factor beta 1 selectively increases gene expression of the serine/threonine kinase receptor 1 (SKR1) in human hepatoma cell lines. Cell Struct Funct 19:305-13
Francavilla, A; Zeng, Q; Polimeno, L et al. (1994) Small-for-size liver transplanted into larger recipient: a model of hepatic regeneration. Hepatology 19:210-6
Inagaki, M; Moustakas, A; Lin, H Y et al. (1993) Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Proc Natl Acad Sci U S A 90:5359-63
Furuya, T; Murase, N; Nakamura, K et al. (1992) Preformed lymphocytotoxic antibodies: the effects of class, titer and specificity on liver vs. heart allografts. Hepatology 16:1415-22
Francavilla, A; Starzl, T E; Carr, B et al. (1991) The effects of FK 506, cyclosporine, and rapamycin on liver growth in vitro and in vivo. Transplant Proc 23:2817-20
Carr, B I; Huang, T H; Itakura, K et al. (1989) TGF beta gene transcription in normal and neoplastic liver growth. J Cell Biochem 39:477-87

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