This population-based, case-control epidemiologic study will examine whethe reproductive factors and exogenous homone use affect women's risk of Hodgkin's disease (HD), a poorly understood lymphoma. HD rates are lower in adult women than men, particularly at reproductive ages. Although the descriptive epidemiology of HD suggests a protective effect of childbearing and both clinical and experimental data show an inhibitory effect of pregnancy on lymphomas, no reproductive or homone-use factors except parity have ever been evaluated regarding HD risk. The two prior studies considering parity and HO risk found strong but opposing associations. This discrepancy requires resolution, and the unexplored hypothesis of hormonal influence on HD risk suggested by existing evidence needs evaluation. Specific study aims are: 1) to detemine if parity protects against HD risk, and if the effect is long-term or temporary (suggesting tumor suppression during pregnancy);2) to determine whether other reproductive factors independently affect HD risk; 3) toexplore the effects of exogenous hormone use on HD risk; 4) to examine the above risks among histologic-type subgroups; 5) to control throughout for potential confounders (e.g., social class). The proposed 5-year study will include 315 women newly diagnosed with histologically confirmed HD, and 315 control women, from 9 counties in the San Francisco Bay Area. Cases will be ascertained through population-based tumor registries. Population-based controls will be identified by random-digit dialing, and requency-matched to cases on age, race and phone number area-code and Prefix. All subjects ill be interviewed in person about demographics (including social status); medical istory; menstrual and fertility history; reproductive experience (age at, duration of and utcome of each pregnancy; lactation); and exogenou hormone use. Relative risks assocated with study factors will be estimated with logistic regression methods for HD overall nd by histologic subtype, with adjustment for social class and other confounders. Study trengths include: 1) a new and feasible approach to investigating the etiology of a cancer hat, by affecting young as well as older persons, is of particular public health concern; thorough examination of the hormone-influence hypothesis through investigation of a full factors; 3) use of population-based cases, for complete, unbiased ugh subjects to detect 2- to 3-fold associated risks for HD overall type; 4) use of population-based controls, reducing biases from s; and 5) detailed attention to suspected confounding factors,

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA050381-04
Application #
3459541
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-09-30
Project End
1994-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Northern California Cancer Center
Department
Type
DUNS #
City
Fremont
State
CA
Country
United States
Zip Code
94538
Glaser, Sally L; Chang, Ellen T; Horning, Sandra J et al. (2007) Understanding the validity of self-reported positive family history of lymphoma in extended families to facilitate genetic epidemiology and clinical practice. Leuk Lymphoma 48:1110-8
Keegan, Theresa H M; Chang, Ellen T; John, Esther M et al. (2007) Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004. Breast Cancer Res 9:R62
Keegan, Theresa H M; Glaser, Sally L; Clarke, Christina A et al. (2006) Body size, physical activity, and risk of Hodgkin's lymphoma in women. Cancer Epidemiol Biomarkers Prev 15:1095-101
Keegan, Theresa H M; Glaser, Sally L; Clarke, Christina A et al. (2005) Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study. J Clin Oncol 23:7604-13
Glaser, Sally L; Keegan, Theresa H M; Clarke, Christina A et al. (2005) Exposure to childhood infections and risk of Epstein-Barr virus--defined Hodgkin's lymphoma in women. Int J Cancer 115:599-605
Glaser, Sally L; Keegan, Theresa H M; Clarke, Christina A et al. (2004) Smoking and Hodgkin lymphoma risk in women United States. Cancer Causes Control 15:387-97
Glaser, Sally L; Clarke, Christina A; Nugent, Rebecca A et al. (2003) Reproductive factors in Hodgkin's disease in women. Am J Epidemiol 158:553-63
Glaser, Sally L; Clarke, Christina A; Gulley, Margaret L et al. (2003) Population-based patterns of human immunodeficiency virus-related Hodgkin lymphoma in the Greater San Francisco Bay Area, 1988-1998. Cancer 98:300-9
Glaser, Sally L; Hsu, Joe L (2002) Hodgkin's disease in Asians: incidence patterns and risk factors in population-based data. Leuk Res 26:261-9
Glaser, Sally L; Clarke, Christina A; Nugent, Rebecca A et al. (2002) Social class and risk of Hodgkin's disease in young-adult women in 1988-94. Int J Cancer 98:110-7

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