Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA051539-02
Application #
3459791
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1989-12-01
Project End
1990-12-31
Budget Start
1990-12-01
Budget End
1990-12-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Simon, C; Juarez, J; Nicolson, G L et al. (1996) Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion. Cancer Res 56:5369-74
Lengyel, E; Klostergaard, J; Boyd, D (1995) Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors. Biochim Biophys Acta 1268:65-72
Wang, H; Skibber, J; Juarez, J et al. (1994) Transcriptional activation of the urokinase receptor gene in invasive colon cancer. Int J Cancer 58:650-7
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Clayman, G; Wang, S W; Nicolson, G L et al. (1993) Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity. Int J Cancer 54:73-80
Juarez, J; Clayman, G; Nakajima, M et al. (1993) Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity. Int J Cancer 55:10-8
Hollas, W; Soravia, E; Mazar, A et al. (1992) Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line. Biochem J 285 ( Pt 2):629-34
Hoosein, N M; Boyd, D D; Hollas, W J et al. (1991) Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines. Cancer Commun 3:255-64
Hollas, W; Blasi, F; Boyd, D (1991) Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res 51:3690-5
Schlechte, W; Brattain, M; Boyd, D (1990) Invasion of extracellular matrix by cultured colon cancer cells: dependence on urokinase receptor display. Cancer Commun 2:173-9

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