Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA055293-05
Application #
2096506
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1991-07-01
Project End
1997-12-31
Budget Start
1995-07-01
Budget End
1997-12-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Jucker, M; Schiffer, C A; Feldman, R A (1997) A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells. Blood 89:2024-35
Jucker, M; McKenna, K; da Silva, A J et al. (1997) The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling. J Biol Chem 272:2104-9
Izuhara, K; Feldman, R A; Greer, P et al. (1996) Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase. Blood 88:3910-8
Jucker, M; Feldman, R A (1995) Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase. J Biol Chem 270:27817-22
Areces, L B; Dello Sbarba, P; Jucker, M et al. (1994) Functional specificity of cytoplasmic and transmembrane tyrosine kinases: identification of 130- and 75-kilodalton substrates of c-fps/fes tyrosine kinase in macrophages. Mol Cell Biol 14:4606-15
Izuhara, K; Feldman, R A; Greer, P et al. (1994) Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor. J Biol Chem 269:18623-9
Areces, L B; Jucker, M; San Miguel, J A et al. (1993) Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit. Proc Natl Acad Sci U S A 90:3963-7