Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA056803-05
Application #
2097602
Study Section
Pathology B Study Section (PTHB)
Project Start
1992-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Gao, Q; Srinivasan, S; Boyer, S N et al. (1999) The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol Cell Biol 19:733-44
Band, V (1998) The role of retinoblastoma and p53 tumor suppressor pathways in human mammary epithelial cell immortalization. Int J Oncol 12:499-507
Cao, Y; Gao, Q; Wazer, D E et al. (1997) Abrogation of wild-type p53-mediated transactivation is insufficient for mutant p53-induced immortalization of normal human mammary epithelial cells. Cancer Res 57:5584-9
Fukazawa, T; Miyake, S; Band, V et al. (1996) Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem 271:14554-9
Dalal, S; Gao, Q; Androphy, E J et al. (1996) Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells. J Virol 70:683-8
Boyer, S N; Wazer, D E; Band, V (1996) E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res 56:4620-4
Gao, Q; Hauser, S H; Liu, X L et al. (1996) Mutant p53-induced immortalization of primary human mammary epithelial cells. Cancer Res 56:3129-33
Wazer, D E; Liu, X L; Chu, Q et al. (1995) Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc Natl Acad Sci U S A 92:3687-91
Band, V (1995) Preneoplastic transformation of human mammary epithelial cells. Semin Cancer Biol 6:185-92
Chen, J J; Reid, C E; Band, V et al. (1995) Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269:529-31

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