New Protooncogene, Int 5, in Breast Neoplasia

Tekmal, Rajeshwar Rao

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29CA057559-05
• Application #: 2098285
• Study Section: Reproductive Endocrinology Study Section (REN)
• Project Start: 1992-08-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1998-05-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Emory University
• Department: Obstetrics & Gynecology
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Atlanta
• State: GA
• Country: United States
• Zip Code: 30322

Publications

Fowler, K A; Gill, K; Kirma, N et al. (2000) Overexpression of aromatase leads to development of testicular leydig cell tumors : an in vivo model for hormone-mediated TesticularCancer. Am J Pathol 156:347-53

Tekmal, R R; Keshava, N (1997) Role of MMTV integration locus cellular genes in breast cancer. Front Biosci 2:d519-26

Tekmal, R R; Durgam, V R (1997) A novel in vitro and in vivo breast cancer model for testing inhibitors of estrogen biosynthesis and its action using mammary tumor cells with an activated int-5/aromatase gene. Cancer Lett 118:21-8

Tekmal, R R; Ramachandra, N; Gubba, S et al. (1996) Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Res 56:3180-5

Tekmal, R R; Durgam, V R (1995) The overexpression of int-5/Aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation. Cancer Lett 88:147-55

Durgam, V R; Easton, J A; Surya, R et al. (1995) Structure of the int-5, a novel MMTV integration genomic locus containing mouse early transposon LTR homology region. Biochim Biophys Acta 1263:89-92

Durgam, V R; Tekmal, R R (1994) The nature and expression of int-5, a novel MMTV integration locus gene in carcinogen-induced mammary tumors. Cancer Lett 87:179-86