Differentiation & Apoptosis in Colonic Epithelial Cells

Heerdt, Barbara

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29CA059932-03
• Application #: 2100543
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1994-01-01
• Project End: 1998-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Montefiore Medical Center (Bronx, NY)
• City: New York
• State: NY
• Country: United States
• Zip Code: 10467

Publications

Heerdt, B G; Houston, M A; Anthony, G M et al. (1999) Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity. Cancer Res 59:1584-91

Heerdt, B G; Houston, M A; Anthony, G M et al. (1998) Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer Res 58:2869-75

Heerdt, B G; Houston, M A; Augenlicht, L H (1997) Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function. Cell Growth Differ 8:523-32

Heerdt, B G; Houston, M A; Rediske, J J et al. (1996) Steady-state levels of mitochondrial messenger RNA species characterize a predominant pathway culminating in apoptosis and shedding of HT29 human colonic carcinoma cells. Cell Growth Differ 7:101-06

Augenlicht, L; Velcich, A; Heerdt, B G (1995) Short-chain fatty acids and molecular and cellular mechanisms of colonic cell differentiation and transformation. Adv Exp Med Biol 375:137-48