Topoisomerase II Mutation Mediated Drug Resistance

Chan, Victor T.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29CA060154-04
• Application #: 2100805
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1994-01-01
• Project End: 1998-12-31
• Budget Start: 1996-01-01
• Budget End: 1996-12-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Ohio State University
• Department: Obstetrics & Gynecology
• Type: Schools of Medicine
• DUNS #: 098987217
• City: Columbus
• State: OH
• Country: United States
• Zip Code: 43210

Publications

Chan, V T (1998) Preparation and use of nonradioactive hybridization probes. Methods Mol Biol 80:377-84

Wang, H; Jiang, Z g; Wong, Y W et al. (1997) Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226. Biochem Biophys Res Commun 237:217-24

Ng, S W; Eder, J P; Schnipper, L E et al. (1995) Molecular cloning and characterization of the promoter for the Chinese hamster DNA topoisomerase II alpha gene. J Biol Chem 270:25850-8