Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA060881-04
Application #
2101658
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Visscher, D W; Nanjia-Makker, P; Heppner, G et al. (2001) Tamoxifen suppresses histologic progression to atypia and DCIS in MCFIOAT xenografts, a model of early human breast cancer. Breast Cancer Res Treat 65:41-7
Shekhar, M P; Werdell, J; Santner, S J et al. (2001) Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res 61:1320-6
Shekhar, M P; Werdell, J; Tait, L (2000) Interaction with endothelial cells is a prerequisite for branching ductal-alveolar morphogenesis and hyperplasia of preneoplastic human breast epithelial cells: regulation by estrogen. Cancer Res 60:439-49
Pethe, V; Shekhar, P V (1999) Estrogen inducibility of c-Ha-ras transcription in breast cancer cells. Identification of functional estrogen-responsive transcriptional regulatory elements in exon 1/intron 1 of the c-Ha-ras gene. J Biol Chem 274:30969-78
Shekhar, M P; Nangia-Makker, P; Wolman, S R et al. (1998) Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Am J Pathol 152:1129-32
Shekhar, P V; Chen, M L; Werdell, J et al. (1998) Transcriptional activation of functional endogenous estrogen receptor gene expression in MCF10AT cells: a model for early breast cancer. Int J Oncol 13:907-15
Wang, H; Mohammad, R M; Werdell, J et al. (1998) p53 and protein kinase C independent induction of growth arrest and apoptosis by bryostatin 1 in a highly metastatic mammary epithelial cell line: In vitro versus in vivo activity. Int J Mol Med 1:915-23
Shekhar, P V; Werdell, J; Basrur, V S (1997) Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines. J Natl Cancer Inst 89:1774-82
Shekhar, P V; Miller, F R (1994) Correlation of differences in modulation of ras expression with metastatic competence of mouse mammary tumor subpopulations. Invasion Metastasis 14:27-37