Antitumor Catalytic Antibodies

Wagner, Carston R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 3R29CA061908-04S1
• Application #: 2438205
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1994-01-01
• Project End: 1998-12-31
• Budget Start: 1997-01-01
• Budget End: 1997-12-31
• Support Year: 4
• Fiscal Year: 1997

Institution

• Name: University of Minnesota Twin Cities
• Department: Pharmacology
• Type: Schools of Pharmacy
• DUNS #: 168559177
• City: Minneapolis
• State: MN
• Country: United States
• Zip Code: 55455

Publications

Chang , S; Griesgraber, G W; Southern, P J et al. (2001) Amino acid phosphoramidate monoesters of 3'-azido-3'-deoxythymidine: relationship between antiviral potency and intracellular metabolism. J Med Chem 44:223-31

Iyer, V V; Griesgraber, G W; Radmer, M R et al. (2000) Synthesis, in vitro anti-breast cancer activity, and intracellular decomposition of amino acid methyl ester and alkyl amide phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT). J Med Chem 43:2266-74

Chang, S L; Griesgraber, G; Abraham, T W et al. (2000) Synthesis and antiviral activity of amino acid carbamate derivatives of AZT. Nucleosides Nucleotides Nucleic Acids 19:87-100

Wagner, C R; Chang, S L; Griesgraber, G W et al. (1999) Antiviral nucleoside drug delivery via amino acid phosphoramidates. Nucleosides Nucleotides 18:913-9

Wagner, C R; Ballato, G; Akanni, A O et al. (1997) Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors. Cancer Res 57:2341-5

Abraham, T W; Kalman, T I; McIntee, E J et al. (1996) Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. J Med Chem 39:4569-75