Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA063334-03
Application #
2105114
Study Section
Radiation Study Section (RAD)
Project Start
1994-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Chakrabarti, S; Mahmood, A; Makrigiorgos, G M (1999) Fluorescent labelling of closely-spaced aldehydes induced in DNA by bleomycin-Fe(III). Int J Radiat Biol 75:1055-65
Chakrabarti, S; Kassis, A I; Slayter, H S et al. (1998) Continuous detection of radiation or metal generated hydroxyl radicals within core chromatin particles. Int J Radiat Biol 73:53-63
Makrigiorgos, G M; Chakrabarti, S; Mahmood, A (1998) Fluorescent labelling of abasic sites: a novel methodology to detect closely-spaced damage sites in DNA. Int J Radiat Biol 74:99-109
Botchway, S W; Chakrabarti, S; Makrigiorgos, G M (1998) Novel visible and ultraviolet light photogeneration of hydroxyl radicals by 2-methyl-4-nitro-quinoline-N-oxide (MNO) and 4,4'-dinitro-(2,2')bipyridinyl-N,N'-dioxide (DBD). Photochem Photobiol 67:635-40
Chakrabarti, S; Mahmood, A; Kassis, A I et al. (1996) Generation of hydroxyl radicals by nucleohistone-bound metal-adriamycin complexes. Free Radic Res 25:207-20
Chakrabarti, S; Makrigiorgos, G M; O'Brien, K et al. (1996) Measurement of hydroxyl radicals catalyzed in the immediate vicinity of DNA by metal-bleomycin complexes. Free Radic Biol Med 20:777-83
Makrigiorgos, G M; Folkard, M; Huang, C et al. (1994) Quantification of radiation-induced hydroxyl radicals within nucleohistones using a molecular fluorescent probe. Radiat Res 138:177-85
Makrigiorgos, G M; Bump, E; Huang, C et al. (1994) Accessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study. Int J Radiat Biol 66:247-57