Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA063512-02
Application #
2105410
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-03-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Iyengar, R V; Pawlik, C A; Krull, E J et al. (2001) Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression. Cancer Res 61:3045-52
Danks, M K; Morton, C L; Krull, E J et al. (1999) Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy. Clin Cancer Res 5:917-24
Guichard, S M; Danks, M K (1999) Topoisomerase enzymes as drug targets. Curr Opin Oncol 11:482-9
Pawlik, C A; Houghton, P J; Stewart, C F et al. (1998) Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays. Clin Cancer Res 4:1995-2002
Danks, M K; Whipple, D O; McPake, C R et al. (1998) Differences in epitope accessibility of p53 monoclonal antibodies suggest at least three conformations or states of protein binding of p53 protein in human tumor cell lines. Cell Death Differ 5:678-86
Zamboni, W C; Gajjar, A J; Mandrell, T D et al. (1998) A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma. Clin Cancer Res 4:2537-44
Potter, P M; Pawlik, C A; Morton, C L et al. (1998) Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11). Cancer Res 58:2646-51
Potter, P M; Wolverton, J S; Morton, C L et al. (1998) Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme. Cancer Res 58:3627-32
Wadkins, R M; Danks, M K; Horowitz, L et al. (1998) Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy. Exp Cell Res 241:332-9
Guichard, S M; Morton, C L; Krull, E J et al. (1998) Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase. Clin Cancer Res 4:3089-94

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