Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA063660-03
Application #
2105649
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Lin, J T; Sharma, R; Grady, J J et al. (2001) A flow cell assay for evaluation of whole cell drug efflux kinetics: analysis of paclitaxel efflux in CCRF-CEM leukemia cells overexpressing P-glycoprotein. Drug Metab Dispos 29:103-10
Awasthi, S; Pandya, U; Singhal, S S et al. (2000) Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1. Chem Biol Interact 128:19-38
Singhal, S S; Awasthi, S; Pandya, U et al. (1999) The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells. Toxicol Lett 109:87-95
Singh, S V; Benson, P J; Hu, X et al. (1998) Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis. Cancer Lett 128:197-204
Morrison, R J; Singhal, S S; Bidani, A et al. (1998) Glutathione S-transferases of rabbit lung macrophages. Toxicol Appl Pharmacol 148:229-36
He, N G; Awasthi, S; Singhal, S S et al. (1998) The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall. Toxicol Appl Pharmacol 152:83-9
Piper, J T; Singhal, S S; Salameh, M S et al. (1998) Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Int J Biochem Cell Biol 30:445-56
Srivastava, S K; Hu, X; Xia, H et al. (1998) ATP-dependent transport of glutathione conjugate of 7beta, 8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene in murine hepatic canalicular plasma membrane vesicles. Biochem J 332 ( Pt 3):799-805
Awasthi, S; Singhal, S S; Srivastava, S K et al. (1998) ATP-Dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity. Biochemistry 37:5231-8
Awasthi, S; Singhal, S S; Pikula, S et al. (1998) ATP-Dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity. Biochemistry 37:5239-48

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