A nuclear matrix protein D-2 that is only present in rat prostate cancer and is not found in normal tissue is the subject of this application. D-2 specific antibodies have been generated. Part of the proposal will include the isolation of monoclonal antibodies to D-2. The cDNA encoding the protein will be cloned. The possible functions of D-2 will be analyzed and its expression in human prostate cancer will be examined.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA065463-04
Application #
2895187
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Mohla, Suresh
Project Start
1996-06-10
Project End
2001-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kim, John J; Yin, Bo; Christudass, Christhunesa S et al. (2013) Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer. J Cell Biochem 114:1286-93