Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA066044-02
Application #
2109276
Study Section
Biochemistry Study Section (BIO)
Project Start
1995-07-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Antoku, K; Maser, R S; Scully Jr, W J et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem Biophys Res Commun 286:1003-10
Fattman, C L; Delach, S M; Dou, Q P et al. (2001) Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene 20:2918-26
Maser, R S; Antoku, K; Scully Jr, W J et al. (2000) Analysis of the role of conserved cysteine residues in the bcl-2 oncoprotein. Biochem Biophys Res Commun 277:171-8
Johnson, D E; Gastman, B R; Wieckowski, E et al. (2000) Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Cancer Res 60:1818-23
Gastman, B R; Johnson, D E; Whiteside, T L et al. (1999) Caspase-mediated degradation of T-cell receptor zeta-chain. Cancer Res 59:1422-7
Cho, R L; Johnson, D E (1999) Characterization of caspase proteases in cytokine-dependent myeloid progenitor cells using enzyme affinity labeling. J Cell Biochem 73:79-89
Johnson, D E (1998) Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal. Front Biosci 3:d313-24
Antoku, K; Liu, Z; Johnson, D E (1998) IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells. Leukemia 12:682-9
An, B; Johnson, D E; Jin, J R et al. (1998) Bcl-2- and CrmA-inhibitable dephosphorylation and cleavage of retinoblastoma protein during etoposide-induced apoptosis. Int J Mol Med 1:131-6
Antoku, K; Liu, Z; Johnson, D E (1997) Inhibition of caspase proteases by CrmA enhances the resistance of human leukemic cells to multiple chemotherapeutic agents. Leukemia 11:1665-72

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