Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA066140-02
Application #
2109392
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-08-07
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Raffini, Leslie J; Slater, Diana J; Rappaport, Eric F et al. (2002) Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6. Proc Natl Acad Sci U S A 99:4568-73
Smith, Martyn T; Wang, Yunxia; Skibola, Christine F et al. (2002) Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children. Blood 100:4590-3
Felix, C A (2001) Leukemias related to treatment with DNA topoisomerase II inhibitors. Med Pediatr Oncol 36:525-35
Lovett, B D; Strumberg, D; Blair, I A et al. (2001) Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Biochemistry 40:1159-70
Pegram, L D; Megonigal, M D; Lange, B J et al. (2000) t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene. Blood 96:4360-2
Ahuja, H G; Felix, C A; Aplan, P D (2000) Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations. Genes Chromosomes Cancer 29:96-105
Megonigal, M D; Cheung, N K; Rappaport, E F et al. (2000) Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. Proc Natl Acad Sci U S A 97:2814-9
Felix, C A; Hosler, M R; Slater, D J et al. (1999) Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints. Mol Diagn 4:269-83
Felix, C A; Lange, B J (1999) Leukemia in infants. Oncologist 4:225-40
Ahuja, H G; Felix, C A; Aplan, P D (1999) The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. Blood 94:3258-61

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