The foundation for the proposed hypothesis of this application assumes three critical steps to carcinogenesis as studied in the Syrian hamster kidney tumor model: 1) hormonal stimulation, 2) metabolic activation, 3) free radical generation.
The specific aims are to: 1) clone and characterize Syrian hamster ER cDNA; 2) study the effect of metabolic activation/free radical generation of ER gene expression; 3) characterize the role of metabolic/estrogenic potential on cell specific expression of ER proteins on tumorigenesis in hamster kidneys; and 4) investigate the role of metabolic activation of estrogens and the interdependency of, if any, between overexpression and neu suppression.
| Chen, Tzu-An; O'Connor, Teresia M; Hughes, Sheryl O et al. (2013) TV parenting practices: is the same scale appropriate for parents of children of different ages? Int J Behav Nutr Phys Act 10:41 |
| O'Connor, Teresia M; Chen, Tzu-An; Baranowski, Janice et al. (2013) Physical activity and screen-media-related parenting practices have different associations with children's objectively measured physical activity. Child Obes 9:446-53 |
| Baranowski, Tom; Abdelsamad, Dina; Baranowski, Janice et al. (2012) Impact of an active video game on healthy children's physical activity. Pediatrics 129:e636-42 |
