Retinoid Signaling in Human Bronchial Epithelial Cell

Kurie, Jonathan M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 5R29CA067353-02
• Application #: 2111015
• Study Section: Metabolic Pathology Study Section (MEP)
• Project Start: 1995-04-01
• Project End: 2000-03-31
• Budget Start: 1996-04-01
• Budget End: 1997-03-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Texas MD Anderson Cancer Center
• Department: Internal Medicine/Medicine
• Type: Other Domestic Higher Education
• DUNS #: 001910777
• City: Houston
• State: TX
• Country: United States
• Zip Code: 77030

Publications

Sueoka, N; Lee, H Y; Wiehle, S et al. (2000) Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene 19:4432-6

Sueoka, N; Lee, H Y; Walsh, G L et al. (2000) Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment. Am J Respir Cell Mol Biol 23:297-303

Lee, H Y; Suh, Y A; Robinson, M J et al. (2000) Stress pathway activation induces phosphorylation of retinoid X receptor. J Biol Chem 275:32193-9

Sueoka, N; Lee, H Y; Walsh, G L et al. (1999) Posttranslational mechanisms contribute to the suppression of specific cyclin:CDK complexes by all-trans retinoic acid in human bronchial epithelial cells. Cancer Res 59:3838-44

Lee, H Y; Sueoka, N; Hong, W K et al. (1999) All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Mol Cell Biol 19:1973-80

Lee, H Y; Chaudhary, J; Walsh, G L et al. (1998) Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells. Oncogene 16:3039-46

Lee, H Y; Dohi, D F; Kim, Y H et al. (1998) All-trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor- dependent signaling pathway. J Clin Invest 101:1012-9

Lee, H Y; Walsh, G L; Dawson, M I et al. (1998) All-trans-retinoic acid inhibits Jun N-terminal kinase-dependent signaling pathways. J Biol Chem 273:7066-71

Han, G R; Dohi, D F; Lee, H Y et al. (1997) All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway. J Biol Chem 272:13711-6

Lee, H Y; Dawson, M I; Claret, F X et al. (1997) Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells. Cell Growth Differ 8:283-91