Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29CA067985-03
Application #
2111811
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-09-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Banda, Douglas M; Nuñez, Nicole N; Burnside, Michael A et al. (2017) Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine. Free Radic Biol Med 107:202-215
Manlove, Amelia H; McKibbin, Paige L; Doyle, Emily L et al. (2017) Structure-Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase. ACS Chem Biol 12:2335-2344
Wickramaratne, Susith; Banda, Douglas M; Ji, Shaofei et al. (2016) Base Excision Repair of N(6)-Deoxyadenosine Adducts of 1,3-Butadiene. Biochemistry 55:6070-6081
Woods, Ryan D; O'Shea, Valerie L; Chu, Aurea et al. (2016) Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. Nucleic Acids Res 44:801-10
Brinkmeyer, Megan K; David, Sheila S (2015) Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1. DNA Repair (Amst) 34:39-51
Ono, Toshikazu; Wang, Shenliang; Koo, Chi-Kin et al. (2012) Direct fluorescence monitoring of DNA base excision repair. Angew Chem Int Ed Engl 51:1689-92
Brinkmeyer, Megan K; Pope, Mary Ann; David, Sheila S (2012) Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays. Chem Biol 19:276-86
Engstrom, Lisa M; Partington, Olga A; David, Sheila S (2012) An iron-sulfur cluster loop motif in the Archaeoglobus fulgidus uracil-DNA glycosylase mediates efficient uracil recognition and removal. Biochemistry 51:5187-97
Raetz, Alan G; Xie, Yali; Kundu, Sucharita et al. (2012) Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells. Carcinogenesis 33:2301-9
Michelson, Anna Zhachkina; Rozenberg, Aleksandr; Tian, Yuan et al. (2012) Gas-phase studies of substrates for the DNA mismatch repair enzyme MutY. J Am Chem Soc 134:19839-50

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