Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29CA068125-02
Application #
2008935
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-08-15
Project End
2000-07-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Louisville
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40292
Cherian, M George; Kang, Y James (2006) Metallothionein and liver cell regeneration. Exp Biol Med (Maywood) 231:138-44
Kang, Y James; Sun, Xiuhua; Chen, Yan et al. (2002) Inhibition of doxorubicin chronic toxicity in catalase-overexpressing transgenic mouse hearts. Chem Res Toxicol 15:1-6
Sun, X; Zhou, Z; Kang, Y J (2001) Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. Cancer Res 61:3382-7
Wang, G W; Klein, J B; Kang, Y J (2001) Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther 298:461-8
Lambert, J C; Wang, G W; Kang, Y J (2001) Zinc inhibition of caspase-3 activation does not protect HeLa cells from apoptotic cell death. Toxicol Appl Pharmacol 175:89-93
Wang, G W; Zhou, Z; Klein, J B et al. (2001) Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes. Am J Physiol Heart Circ Physiol 280:H2292-9
Kang, Y J (2001) Molecular and cellular mechanisms of cardiotoxicity. Environ Health Perspect 109 Suppl 1:27-34
Kang, Y J; Zhou, Z X; Wu, H et al. (2000) Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide. Lab Invest 80:745-57
Cai, L; Klein, J B; Kang, Y J (2000) Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage. J Biol Chem 275:38957-60
Zhou, Z; Kang, Y J (2000) Cellular and subcellular localization of catalase in the heart of transgenic mice. J Histochem Cytochem 48:585-94

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