Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29CA071768-01
Application #
2115313
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-07-15
Project End
2001-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arizona
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Jaramillo, Melba C; Briehl, Margaret M; Batinic-Haberle, Ines et al. (2015) Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. Free Radic Biol Med 83:89-100
Briehl, Margaret M (2015) Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students. Redox Biol 5:124-39
Lee, Kristy; Hart, Matthew R; Briehl, Margaret M et al. (2014) The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma. Int J Oncol 45:439-47
Lee, Kristy; Briehl, Margaret M; Mazar, Andrew P et al. (2013) The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. Free Radic Biol Med 60:157-67
Wilkinson, Sarah T; Tome, Margaret E; Briehl, Margaret M (2012) Mitochondrial adaptations to oxidative stress confer resistance to apoptosis in lymphoma cells. Int J Mol Sci 13:10212-28
Jaramillo, Melba C; Briehl, Margaret M; Crapo, James D et al. (2012) Manganese porphyrin, MnTE-2-PyP5+, Acts as a pro-oxidant to potentiate glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med 52:1272-84
Tome, Margaret E; Frye, Jennifer B; Coyle, Donna L et al. (2012) Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance. Exp Ther Med 3:845-852
Tome, Margaret E; Jaramillo, Melba C; Briehl, Margaret M (2011) Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells. Free Radic Biol Med 51:2048-59
Wilkinson, Sarah T; Johnson, David B F; Tardif, Heather L et al. (2010) Increased cytochrome c correlates with poor survival in aggressive lymphoma. Oncol Lett 1:227-230
Jaramillo, Melba C; Frye, Jennifer B; Crapo, James D et al. (2009) Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells. Cancer Res 69:5450-7

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