The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA072572-04
Application #
6164228
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Mufson, R Allan
Project Start
1997-03-01
Project End
2002-02-28
Budget Start
2000-03-01
Budget End
2001-02-28
Support Year
4
Fiscal Year
2000
Total Cost
$105,351
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Ramos, Belen; Lahti, Jill M; Claro, Enrique et al. (2003) Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells. Mol Pharmacol 64:502-11
Hsu, Li-Chung; Liu, Shu; Abedinpour, Ferishteh et al. (2003) The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Mol Cell Biol 23:8773-85
Trembley, Janeen H; Hu, Dongli; Hsu, Li-Chung et al. (2002) PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. J Biol Chem 277:2589-96
Lahti, J M (1999) Use of gene knockouts in cultured cells to study apoptosis. Methods 17:305-12