In this R29 application, studies are proposed to focus on the possible interaction between HIV Rev protein and a recently identified cellular factor termed REBP. Specifically, the interaction of REBP with the leucine-rich effector domain of other lentiviral Rev proteins and cellular export proteins will be examined. The functional relevance of REBP with various retroviral Rev and export proteins will be studied. The critical sequence element in REBP that mediates Rev-REBP interaction will be identified. The subcellular localization of HIV Rev and REBP will be examined by confocal laser microscopy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA073474-02
Application #
2633963
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Cremer, Kenneth J
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103