Enzymatic Studies on Protein Tyrosine Kinase Csk

Agency: National Institute of Health (NIH)
Institute: National Cancer Institute (NCI)
Type: First Independent Research Support & Transition (FIRST) Awards (R29)
Project #: 5R29CA074305-06
Application #: 6376422
Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer: Forry, Suzanne L


NIH 2001 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Johns Hopkins University	$89,994
NIH 2000 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Johns Hopkins University	$98,400
NIH 1999 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Rockefeller University
NIH 1999 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Johns Hopkins University
NIH 1998 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Rockefeller University
NIH 1997 R29 CA	Enzymatic Studies on Protein Tyrosine Kinase Csk Cole, Philip A. / Rockefeller University

Chu, Nam; Salguero, Antonieta L; Liu, Albert Z et al. (2018) Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell 174:897-907.e14

Dempsey, Daniel R; Cole, Philip A (2018) Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol 607:405-422

Chen, Zan; Dempsey, Daniel R; Thomas, Stefani N et al. (2016) Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation. J Biol Chem 291:14160-9

Newman, Robert H; Hu, Jianfei; Rho, Hee-Sool et al. (2013) Construction of human activity-based phosphorylation networks. Mol Syst Biol 9:655

Tarrant, Mary Katherine; Rho, Hee-Sool; Xie, Zhi et al. (2012) Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol 8:262-9

Wang, Zhihong; Longo, Patti A; Tarrant, Mary Katherine et al. (2011) Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nat Struct Mol Biol 18:1388-93

Bellows, M L; Taylor, M S; Cole, P A et al. (2010) Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework. Biophys J 99:3445-53

Qiu, Chen; Tarrant, Mary K; Boronina, Tatiana et al. (2009) In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry 48:6624-32

Muratore, Kathryn E; Seeliger, Markus A; Wang, Zhihong et al. (2009) Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry 48:3378-86