The localization and characterization of tumor suppressor genes has profound implications for prevention and treatment of cancer. The primary goal of this research is to develop statistical tools to expedite the search for tumor suppressor gene candidates.
The specific aims of this research are: to develop statistical significance tests that will help identify tumor suppressor gene candidates from loss of heterozygosity studies and deletion mapping studies; to provide methods for determining whether allelic loss patterns from different groups of patients are significantly different; to produce publicly available software for implementing these procedures; and to estimate biologically important characteristics of the allelic loss process in neoplastic progression. The methods for achieving these aims will involve the formulation of models for genetic events in tumorigenesis, focusing primarily on allelic loss events. Power studies will be performed which will allow scientists to determine the sample sizes to achieve various levels of certainty in the identification of tumor suppressor gene candidates.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA077607-03
Application #
6173102
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Seminara, Daniela
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
3
Fiscal Year
2000
Total Cost
$99,637
Indirect Cost
Name
University of Washington
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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