Several behavioral effects of abused drugs, particularly their reinforcing effects, are altered when experimental subjects are deprived of food. The research proposed here is designed to extend research into fundamental relationships between levels of food deprivation and the behavioral effects of the abused drugs cocaine and morphine. Several of the experiments will determine whether food deprivation alters the suppressive effects of cumulative doses of cocaine or morphine on operant (i.e., rewarded) behavior maintained by different reinforcers. Combinations of different levels of food deprivation and doses of drugs will be tested in rats lever-pressing under comparable schedules of food and water reinforcement, and shock avoidance. The effects of a neurochemical consequence of feeding will also be tested by administering drugs in combination with the potent endogenous feeding-inducing peptide, neuropeptide Y. These studies will have general implications for the role nutritional variables play in drug abuse, as well as provide the basis for research on the manner in which behavioral variables influence the nature of drug interactions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DA008053-02
Application #
2120508
Study Section
Special Emphasis Panel (SRCD)
Project Start
1994-06-15
Project End
1999-05-31
Budget Start
1995-06-01
Budget End
1996-05-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
West Virginia University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Lieving, L M; Odum, A L; Schaal, D W (2002) The effects of morphine on chained and clocked fixed-interval schedule performance in pigeons. Behav Pharmacol 13:221-8
Ross, Linda; Schaal, David W (2002) Time of supplemental feeding alters the effects of cocaine on lever pressing of rats. J Exp Anal Behav 77:199-208
Knealing, Todd W; Schaal, David W (2002) Disruption of temporally organized behavior by morphine. J Exp Anal Behav 77:157-69
Schaal, D W; Odum, A L; Shahan, T A (2000) Pigeons may not remember the stimuli that reinforced their recent behavior. J Exp Anal Behav 73:125-39
Odum, A L; Schaal, D W (2000) The effects of morphine on fixed-interval patterning and temporal discrimination. J Exp Anal Behav 74:229-43
Odum, A L; Schaal, D W (1999) The effects of morphine on clocked fixed-interval performance: stimulus function or strength of stimulus control? Behav Pharmacol 10:243-55
Odum, A L; Haworth, S C; Schaal, D W (1998) Food-deprivation level alters the effects of morphine on pigeons' key pecking. J Exp Anal Behav 69:295-310
Schaal, D W (1996) Representing within-session response rates proportionally and entirely. J Exp Anal Behav 66:135-41
Schaal, D W; McDonald, M P; Miller, M A et al. (1996) Discrimination of methadone and cocaine by pigeons without explicit discrimination training. J Exp Anal Behav 66:193-203
Schaal, D W; Miller, M A; Odum, A L (1995) Cocaine's effects on food-reinforced pecking in pigeons depend on food-deprivation level. J Exp Anal Behav 64:61-73